2012 Fiscal Year Final Research Report
Regulatory mechanism of TOR signaling in response to glucose
| Project/Area Number |
23770230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
TATEBE Hisashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00596819)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分裂酵母 / TORC2 / Akt / Gタンパク質 |
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| Research Abstract |
The TORC2 - Akt pathway is evolutionarily conserved from yeast to human. Whereas the human TORC2 pathway responds to glucose via insulin stimuli, the TORC2 pathway in a unicellular organism fission yeast directly recognizes glucose in the extracellular environment, although precise molecular mechanism how the TORC2 pathway is activated upon insulin stimuli or glucose in those organisms has remained elusive. In this study, we utilized fission yeast as a model organism and revealed that activity of Ryh1, a known activator of TORC2, is regulated in response to glucose.
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[Journal Article] A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen2013
Author(s)
Komeda, C., Ikeda, A., Kikuchi, J., Ishida-Kitagawa, N., Tatebe, H., Shiozaki, K., and Akiyama, M.
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Journal Title
Org Biomol Chem
Volume: 11
Pages: 2567-570
DOI
Peer Reviewed
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