2013 Fiscal Year Final Research Report
Molecular mechanism for pattern formation
| Project/Area Number |
23770247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | パターン形成 / ゼブラフィッシュ / 体表模様 / 細胞間相互作用 / 細胞境界 |
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| Research Abstract |
The purpose of this project is to analyze molecular mechanism of boundary formation between cells. Zebrafish stripe consists of two types of pigment cells, melanophores and xanthophores. We analyzed pigment pattern mutant, dali, which shows intermingled pigment pattern of melanophores and xanthophores. We identified an amino acid substitution in Tetraspanin 3C (Tespan3C) protein which has a function to anchor membrane proteins at cell surface. The mutation caused defects in protein modification of Tespan3C and in cell migration activity of melanophore. Furthermore we detected the loss of repulsive interaction between melanophore and xanthophore, which caused intermingled pigment pattern of the mutant fish.
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Research Products
(17 results)
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[Journal Article] Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning2014
Author(s)
Hamada, H., Watanabe, M., Lau H. E., Nishida, T., Hasegawa, T., Parichy D. M. & Kondo, S.
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Journal Title
Development
Volume: 141
Pages: 318-324
DOI
Peer Reviewed
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[Journal Article] Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule, igsf112012
Author(s)
Eom, D.-S., Inoue, S., Patterson, L. B., Gordon, T. N., Slingwine, R., Kondo, S., Watanabe, M. & Parichy, D. M.
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Journal Title
PLoS Genet
Volume: 8(8)
Pages: e1002899
DOI
Peer Reviewed
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