2012 Fiscal Year Final Research Report
Specification of sensory primordia by the synergistic action of SOX2 and its partner factor
| Project/Area Number |
23770248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞分化 / 発現制御 / 感覚器原基 / エンハンサー / Sox2 / Sall4 |
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| Research Abstract |
Sensory tissues, e.g. olfactory epithelium, inner ear and lens, develop from cephalic ectoderm through progressive specification steps. The transcription factor gene Sox2 is consistently expressed in the sensory primordia regardless of developmental stages, owing to the sequential activation of stage-/placode-specific enhancers. The NOP1 enhancer is specifically active in the nasal and otic placodes. An essential activating element of NOP1 enhancer was shown to be regulated by the synergistic action of Sox2 and Sall4, as well as Sox9 and Sall4 (but not Sox11 and Sall4). Inhibition of Sox activity in the posterior cephalic ectoderm inactivated the NOP1 enhancer. These data indicate that Sox-Sall4 synergism is essential for Sox2regulation in the nasal and otic placodes.
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