2012 Fiscal Year Final Research Report
The molecular mechanism for the regulation of neural stem cell proliferation in Drosophila
| Project/Area Number |
23770262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2012)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
KANAI Makoto 公益財団法人大阪バイオサイエンス研究所, 神経生物学部門, 研究員 (50598034)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経幹細胞 / ショウジョウバエ / グリア細胞 / ニッチ / HSPG / TGFβ |
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| Research Abstract |
Stemness is largely defined by neighboring tissues and cells called niche. To determine the contribution of glial cell niche for the proliferation of neural stem cell, I used Drosophila neuroblast as a model and found that glial cells and neuroblasts are in physical contact, on which they interact to regulate neuroblast proliferation with the distinct molecules that are mutually expressed on the each cell surface.
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