Functional associations between biological clock systems and sleep homeostasis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23770289
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied anthropology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: KITAMURA Shingo 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 科研費研究員 (80570291)
• Project Period (FY): 2011 – 2013
• Keywords: 睡眠恒常性 / 生体リズム / 日周指向性

Research Abstract

Little is known about the pathophysiology of drifting sleep patterns in circadian rhythm sleep disorder, free-running type (FRT). This is the first report that successfully detected a prolonged circadian rhythm period (τ) in sighted patients with FRT compared to controls with normal sleep habits using a 7-day, 28-h forced desynchrony protocol. As the prolonged τ was also observed in a subset of night owl people, the pathophysiology of FRT is not only explained by the abnormal τ, thus pointing out the multilayered nature of FRT.

Research Products

• [Journal Article] Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type (2013)
  • Author(s): Kitamura S, Hida A, Enomoto M, Watanabe M, Katayose Y, Nozaki K, Aritake S, Higuchi S, Moriguchi Y, Kamei Y, Mishima K
  • Journal Title: Biol Psychiatry Volume: 73(1) Pages: 63-69
  • DOI: doi:10.1016/j.biopsych.2012.06.027.
  • Peer Reviewed
• [Journal Article] Sleep debt elicits negative emotional reaction through diminished amygdala-anterior cingulate functional connectivity (2013)
  • Author(s): Motomura Y, Kitamura S, Oba K, Terasawa Y, Enomoto M, Katayose Y, Hida A, Moriguchi Y, Higuchi S, Mishima K
  • Journal Title: PLoS One Volume: 8(2)
  • DOI: doi:10.1371/journal.pone.0056578.
  • Peer Reviewed
• [Journal Article] Rhythmic expression of circadian clock genes in human leukocytes and beard hair follicle cells (2012)
  • Author(s): Watanabe M, Hida A, Kitamura S, Enomoto M, Ohsawa Y, Katayose Y, Nozaki K, Moriguchi Y, Aritake S, Higuchi S, Tamura M, Kato M, Mishima K
  • Journal Title: Biochem Biophys Res Commun Volume: 425(4) Pages: 902-907
  • DOI: doi:10.1016/j.bbrc.2012.08.008.
  • Peer Reviewed
• [Journal Article] Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans (2012)
  • Author(s): Aritake S, Higuchi S, Suzuki H, Kuriyama K, Enomoto M, Soshi T, Kitamura S, Hida A, Mishima K
  • Journal Title: BMC Neurosci Volume: 13(1) Pages: 153
  • DOI: doi:10.1186/1471-2202-13-153.
  • Peer Reviewed
• [Journal Article] Pathophysiology and pathogenesis of circadian rhythm sleep disorders (2012)
  • Author(s): Hida A, Kitamura S, Mishima K.
  • Journal Title: J Physiol Anthropol Volume: 31(1)
  • DOI: doi:10.1186/1880-6805-31-7.
  • Peer Reviewed
• [Journal Article] クロノタイプによる睡眠覚醒パターン (2012)
  • Author(s): 北村真吾、肥田昌子、三島和夫
  • Journal Title: 気分調節の特徴.時間生物学 Volume: 18(2) Pages: 68-75
  • URL: http://chronobiology.jp/journal/JSC2012-2-068.pdf
  • Peer Reviewed
• [Presentation] 概日リズム位相による気分変動の個人差 (2012)
  • Author(s): 北村真吾, 肥田昌子, 榎本みのり, 渡邊真 紀子, 片寄泰子, 野崎健太郎, 有竹清夏, 樋 口重和, 守口善也, 亀井雄一, 三島和夫
  • Organizer: 日本生理人類学会第67回大会
  • Place of Presentation: 東京
  • Year and Date: 20121117-18
• [Presentation] うつ病の時間生物学的基盤 (2012)
  • Author(s): 北村真吾
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 20120915-16
• [Presentation] 加齢によるクロノタイプの変化と睡眠特性、抑うつ状態との関連:5 年間追跡調査 (2012)
  • Author(s): 北村真吾, 肥田昌子, 三島和夫
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 20120915-16
• [Presentation] ミュンヘンクロノタイプ質問紙(MCTQ)日本語版の作成 (2012)
  • Author(s): 北村真吾, 肥田昌子, 三島和夫
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 20120915-16
• [Presentation] 小中学生を対象とした睡眠習慣と睡眠問題に関する全国調査 (2012)
  • Author(s): 北村真吾, 榎本みのり, 塚田恵鯉子, 亀井 雄一, 小山智典, 稲田尚子, 森脇愛子, 神尾 陽子, 三島和夫
  • Organizer: 日本睡眠学会第37回定期学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 20120628-30
• [Presentation] An epidemiologic study of sleep-wake patterns and sleep disturbance among japanese school-aged children. 26th Annual Meeting of the Associated Professional Sleep Societies (2012)
  • Author(s): Kitamura S, Enomoto M, Tsukada E, Kamei Y, Koyama T, Moriwaki A, Kamio Y, Mishima K
  • Organizer: LLC A Joint Meeting of the American Academy of Sleep Medicine and the Sleep Research Society
  • Place of Presentation: Boston, John B. Hynes Veterans Memorial Convention Center
  • Year and Date: 20120609-13