2012 Fiscal Year Final Research Report
Identification and functional analysis of O-glycosylated proteins in filamentous fungi
| Project/Area Number |
23780084
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
FUTAGAMI Taiki 九州大学, 大学院・農学研究院, 助教 (60512027)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | O-結合型糖鎖 / 細胞壁ストレス / 糸状菌 / Aspergillus |
|---|
| Research Abstract |
O-glycosylated proteins play an important role in the cell morphogenesis of fungal species. We characterized the putative stress sensor protein ofcell wall integrity (CWI) signaling, Mid2-like protein (MidB), in the Aspergillus nidulans. The disruption of midBshowed the increased sensitivities to the cell wall inhibitors such as Congo red and calcofluor, indicating that the MidB is involved in the CWI in the A. nidulans. However, the MidB was not essential for the downstream MpkA-RlmA signaling that caused a transient transcriptional up-regulation of the agsBgene.
|
