2012 Fiscal Year Final Research Report
Studies on a microbial function induced by light
| Project/Area Number |
23780093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Nihon University |
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Principal Investigator |
TAKANO Hideaki 日本大学, 生物資源科学部, 助教 (50385994)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Photo-response / Transcriptional regulation / LitR / MerR family / Cobalamin / Streptomyces coelicolor / Thermus thermophilus / Pseudomonas putida |
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| Research Abstract |
LitR is an adenosyl Bl2-dependent light-sensitive MerR family transcriptional regulator,and litRhomologues are widely distributed among the Phylogenetically diverse genera of non-Phototrophic bacteria, including gram-positive and gram-negative bacteria. Our study on the function and role of LitR from Thermus and Bacillus revealed that LitrR is a central regulator of the light-inducible carotenoids production in both strains. Furthermore,we showed that LitR protein is an adenosyl B12-dependent light-sensitive regulaor in vivo experiment. We also revealed that LOV type photoreceptor is involved in the LitR-dependent transcriptional regulation in Pseudomonas.
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