2014 Fiscal Year Final Research Report
Understanding the molecular mechanism of trans-translation
| Project/Area Number |
23780099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
KURITA Daisuke 弘前大学, 農学生命科学部, 助教 (60552651)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | リボソーム / tmRNA / SmpB / タンパク合成 / トランスレーション / 翻訳 |
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| Outline of Final Research Achievements |
Ribosomes stalled at the 3’ end of a truncated mRNA lacking a stop codon are rescued by trans-translation mediated by tmRNA and a partner protein SmpB. We revealed how tmRNA and SmpB preferentially recognize stalled ribosomes and not actively translating ones.
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| Free Research Field |
生化学
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