2013 Fiscal Year Final Research Report
Synthetic studies and SAR of the structurally complex indole diterpenes showing strong insecticidal activities
| Project/Area Number |
23780112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2012-2013)
Tohoku University (2011) |
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Principal Investigator |
ENOMOTO Masaru 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 研究員 (90546342)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 天然有機化合物 / indole diterpine / paspalinine / lecanindole D / 全合成 / 構造活性相関 |
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| Research Abstract |
Indole diterpenes are known to possess intriguing biological activity such as insecticidal, mito-inhibitory, and anti-MRSA activities. Therefore, synthetic studies and chemical supply of these compounds could solve the mechanism of action and contribute to development of various biology such as chemical ecology, cell biology, medicinal science. But, it was difficult to synthesis this family of natural products due to their complex structures. In this study, we have developed an efficient method to construct the indole diterpine framework and achieved total synthesis of paspalinine, a tremorgenic alkaloid, and lecanindole D, a progesterone receptor agonist.
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[Presentation] Synthetic Studies on Sg17-1-42013
Author(s)
Tomomi Suzuki, Tomohiro Nagasawa, Masaru Enomoto and Shigefumi Kuwahara
Organizer
International Symposium for the 70^<th> Aniversary of the Tohoku Branch of the Chemical Society of Japan
Place of Presentation
Sendai.
Year and Date
20130928-29
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[Presentation] Total Synthesis of Paspalinine2013
Author(s)
Masaru Enomoto, Akira Morita and Shigefumi Kuwahara
Organizer
13^<th> International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds
Place of Presentation
Yamanashi.
Year and Date
20130924-27
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