2013 Fiscal Year Final Research Report
Synthetic study of microbial metabolite with molecular chaperone production supressing actibity.
| Project/Area Number |
23780121
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KATSUTA Ryo 東京農業大学, 応用生物科学部, 助教 (00553257)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 有機化学 / 天然物化学 / versipelostatin / GRP78 / 抗腫瘍 |
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| Research Abstract |
Recently, an importance of cancer in cause of death is increasing, especially in advanced nations. To improve the new class of anticancer agent, the synthetic study of versipelostatin(VST) A, a microbe derived molecular chaperon suppressor, is performed. In this research program, syntheses of all fragment required for VST synthesis including its specific part, spirotetronate fragment was achieved.
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[Presentation] Synthetic Study of Versipelostatin A2012
Author(s)
Katsuta, R., Yamamoto, K., Arai, K. ,Kowashi,M., Yamashita, A., Yajima, A., Nukada, T
Organizer
The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12
Place of Presentation
Rihga Royal Hotel Kyoto, JAPAN
Year and Date
20121100
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