2012 Fiscal Year Final Research Report
Enzymatic synthesis of polyphenol-glycosides with stimulatory activity on Treg differentiation
| Project/Area Number |
23780129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食品機能 |
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| Research Abstract |
We synthesized newly polyphenol glycosides via a rutinase-catalyzed transglycosylation reaction. We then prepared a newly in vitro assay system using DCs differentiated from human monocytic THP-1 for the screening of anti-allergic compounds. Significant decrease in HLA-DR expression was observed in the apple procyanidins and caffeic acid-rutinosides-treated cells in the stimulation of OVA. These suggest that the newly developed polyphenols glycosides should be contribute to anti-allergic agents with suppressive effect on antigen presentation.
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Research Products
(6 results)
