2013 Fiscal Year Final Research Report

Analysis of true niacin deficiency and its pathogenic mechanisms using QPRT knockout mice

Research Project

Project/Area Number	23780140
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Food science
Research Institution	The University of Shiga Prefecture
Principal Investigator	SANO Mitsue 滋賀県立大学, 人間文化学部, 助教 (20524911)
Project Period (FY)	2011 – 2012
Keywords	栄養生化学 / 水溶性ビタミン / ナイアシン / 分子栄養学 / 栄養化学
Research Abstract	Niacin deficiency was caused in QPRT knockout mice via a niacin-deficient diet, and the resulting biological abnormalities in that condition were analyzed. The present study suggested that the inner circular layer of the small intestine is affected by niacin deficiency, and that gastrointestinal diseases appear with characteristic symptoms of pellagra. In addition, although the effects of niacin on metabolic pathways could not be clarified because of the influence of simultaneously occurring nutritional deficiency, the necessity of continuing future analysis without reducing the amount of food intake was apparent.