2012 Fiscal Year Final Research Report
Functional analyses of androgen and food factor in insulin secretion
| Project/Area Number |
23780141
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
HARADA Naoki 大阪府立大学, 生命環境科学研究科, 助教 (00529141)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アンドロゲン受容体 / 2 型糖尿病 / 膵β細胞 / S-エクオール / 大豆イソフラボン / インスリン |
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| Research Abstract |
Defects in insulin secretion by decreasing pancreatic β-cell mass are frequently observed in patients with type 2 diabetes in eastern country. We have demonstrated that male sexual hormone (testosterone) enhanced the proliferation of β-cellthrough androgen receptor (AR). The growth stimulating effects of testosterone was diminished under high glucose conditions, which decreased AR protein. We also found that S-equol, which is produced from the soy isoflavone daidzein, enhanced β-cell growth.
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