2012 Fiscal Year Final Research Report
Searoh for prote ins that determine the food function-focusing on the oxidative modification of cysteirle residues
| Project/Area Number |
23780145
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
HOSONO Takashi 日本大学, 生物資源科学部, 助教 (80445741)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 栄養生化学 / 食品機能 / システイン / 薬物代謝酵素 / CYP2E1 |
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| Research Abstract |
Oxidative modification of cysteine residues is one of the post-translational regulations in the proteinfunction.In this study. the oxidative modification of the SH group at Cys-437 in CYP2E molecule was detected, and this modification was causative of the inhibition of the CYP2E1 activity by DATS.Further analyses on the function of proteins which had been oxidized by DATS, will clarify the novelfunctions of food components such as DATS.
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Research Products
(9 results)
