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2012 Fiscal Year Final Research Report

The analytical method of post-translational modification to proteins related to the neurodegenerative disorder.

Research Project

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Project/Area Number 23780147
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionMeijo University

Principal Investigator

HISAKA Shinsuke  名城大学, 薬学部, 助教 (60583838)

Project Period (FY) 2011 – 2012
Keywords翻訳後修飾 / 脂質過酸化 / モノクローナル抗体 / ELISA / 酸化ストレス
Research Abstract

In this study, the monoclonal antibodies, which could recognize the propanoylation, one of non-enzymatic post-translational modification derived from lipid peroxidation products in addition to amino acid sequences of the target protein, were obtained to construct the quantification method of biomarker related to the neurodegenerative disorder. We constructed the competitive ELISA using this antibody and prepared the standard curve. These results suggested that it was possible to quantify the level of this modification in vivo as the biomarker.

  • Research Products

    (4 results)

All 2012 2011

All Presentation (4 results)

  • [Presentation] アミロイドbタンパク質における脂質過酸化に由来する翻訳後修飾の解析2012

    • Author(s)
      日坂真輔
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡県(福岡国際会議場・マリンメッセ福岡)
    • Year and Date
      2012-12-15
  • [Presentation] 多価不飽和脂肪酸は酸化ストレスを介して神経変性疾患を惹起しうるか2012

    • Author(s)
      日坂真輔
    • Organizer
      フォーラム2012衛生薬学・環境トキシコロジー
    • Place of Presentation
      愛知県(名古屋観光ホテル)
    • Year and Date
      2012-10-25
  • [Presentation] 脂質過酸化に由来するタンパク質の翻訳後修飾の解析2012

    • Author(s)
      日坂真輔
    • Organizer
      日本酸化ストレス学会東海支部設立シンポジウム、発表年月日
    • Place of Presentation
      愛知県(鶴友会館)
    • Year and Date
      2012-02-18
  • [Presentation] 神経変性疾患関連タンパク質における脂質過酸化に由来する翻訳後修飾の解析2011

    • Author(s)
      日坂真輔
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都府(京都国際会館)
    • Year and Date
      2011-09-24

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Published: 2014-09-25  

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