2013 Fiscal Year Final Research Report
Analysis of molecular mechanism of gastric mucosal damage by aberrant regulation of calpain
| Project/Area Number |
23780152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HATA Shoji 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (10392375)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カルパイン / 胃粘膜防御 |
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| Research Abstract |
There are various, complex defense systems in gastrointestinal mucosae exposed usually by external stresses. Calpain-8 (CAPN8) and calpain-9(CAPN9), intracellular Ca2+-dependent proteases specifically expressed in mucus-secreting cells in gastrointestinal epithelia, form a complex named G-calpain, and are involved in gastric mucosal defense induced by external stresses.This study identified the significance of the complex formation by CAPN8 and CAPN9, and suggested that G-calpain is involved in mucosal defense via regulation of migration of the mucus-secreting cells.
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