2012 Fiscal Year Final Research Report
Identification of the genes of which expression was regulated by the circadian clock in the mouse ovaries using microarray analysis
| Project/Area Number |
23780280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | Kinki University |
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Principal Investigator |
AMANO Tomoko 近畿大学, 生物理工学部, 講師 (60388585)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 時計遺伝子 / 卵巣機能 |
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| Research Abstract |
To identify the genes of which transcriptions are regulated by the circadian genes (Clock controlled genes: CCGs) in the mouse ovaries, we compared the gene expression in the ovaries of the mice bearing deficiencies of the circadian genes, Clock mutant mice and Per1/Per2 knockout mice, with that of the ovaries of wild type mice by microarray analysis. As a result, we detected some genes known to regulate reproductive ability in females including StAR. We will examine the interaction of the circadian genes on the promoter region of those genes in our next experiments.
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