The mechanism for the hypoglycaemia induced suppression of gonadal function in the pituitary gland

2013 Fiscal Year Final Research Report

• Project/Area Number: 23780282
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied animal science
• Research Institution: Kinki University
• Principal Investigator: MORIYAMA Ryutaro 近畿大学, 理工学部, 講師 (30411573)
• Project Period (FY): 2011 – 2013
• Keywords: 低血糖 / LH / FSH / AMPK / 下垂体 / 性腺刺激ホルモン産生細胞 / 性腺機能 / 低栄養

Research Abstract

In the present study, we observed the restriction of glucose availability induced the transcriptional suppression of luteinizing hormone beta subunit (LHbeta) and follicle-stimulating hormone beta subunit (FHSbeta) genes via AMP-activated protein kinase (AMPK) signaling pathway in the gonadotropic LbetaT2 cell line. The result suggests a possibility that gonadotrophs of the pituitary gland participate in nutritional disorders inducing reproductive dysfunction in many mammalian species from cattle to humans.

Research Products

• [Journal Article] Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse (2013)
  • Author(s): S. M. Popa, R. M. Moriyama, C. S. Caligioni, C. M. Cho, T. L. Concepcion, A. E. Oakley, I. H. Lee, E. Sanz, P. S. Amieux, A. Caraty, R. D. Palmiter, V. M. Navarro, Y.-M. Chan, S. B. Seminara, D. K. Clifton, A. Steiner
  • Journal Title: Endocrinology Volume: Vol. 154, Issue 8 Pages: 2784-2794
  • Peer Reviewed
• [Journal Article] Fukushima, Lysophosphatidic acid induces neurite branch formation through LPA3 (2012)
  • Author(s): D. Furuta, M. Yamane, T. Tsujiuchi, R. Moriyama, and N.
  • Journal Title: Molecular and Cellular Neuroscience Volume: Vol.50, Issue 1 Pages: 21-34
  • Peer Reviewed
• [Presentation] 長鎖脂肪酸への暴露がマウス精子の運動性に与える影響 (2013)
  • Author(s): 森山隆太郎、若狭郁美、中川雅子
  • Organizer: 第106回日本繁殖生物学会大会
  • Place of Presentation: 府中、東京農工大学
  • Year and Date: 2013-09-13
• [Presentation] マウス下垂体のα-subunit含有細胞に局在するリゾホスファチジン酸受容体1 mRNAの発現量は去勢により増加する (2013)
  • Author(s): 森山隆太郎,松本絵美,原玲奈,宮里公子,十河由紀,福嶋伸之
  • Organizer: 第28回下垂体研究会学術集会
  • Place of Presentation: 花巻温泉、ホテル千住閣
  • Year and Date: 2013-08-07
• [Presentation] A Peripherally-Restricted Kappa Agonist (PRKA) as a Novel Approach to the Treatment of Menopausal Hot Flashes (2013)
  • Author(s): A. E. Oakley, R. Million, L. W. Organick, R. Moriyama, K. E. Manbeck, J. R. Levin, D. Reed, C. Chavkin, D. K. Clifton, R.t A. Steiner
  • Organizer: Endocrine Society's 95^<th> Annual Meeting & Expo (ENDO2013)
  • Place of Presentation: San Francisco, California
  • Year and Date: 2013-06-17
• [Presentation] Metabolic Regulation of Reproduction : The Effects of AgRP Neuronal Ablation on Kiss1 Expression in Leptin-Deficient Mice (2012)
  • Author(s): R. Million, A. E. Oakley, R. Moriyama, D.K. Clifton, R.A. Steiner
  • Organizer: 2012 Annual Biomedical Research Conference for Minority Students (ABRCMS)
  • Place of Presentation: San Jose, California(B049)
  • Year and Date: 2012-11-08
• [Presentation] Fertility in the Presence of Minute Levels of Kisspeptin (2012)
  • Author(s): S. M. Popa, R. M. Moriyama, C. Cho, T. L. Concepcion, A. E. Oakley, I. H. Lee, E. Sanz, C. S. Caligioni, Yee-Ming Chan, S. B. Seminara, V. M. Navarro, D. K Clifton, R. A. Steiner
  • Organizer: 2^<nd> World Conference of Kisspeptin signaling in the brain
  • Place of Presentation: University of Tokyo, Tokyo
  • Year and Date: 2012-11-07
• [Presentation] The role of kisspeptin in the restriction of fertility following ablation of Agouti-related peptide (AGRP) neurons in the leptin-deficient mice (2012)
  • Author(s): A. E. Oakley, I. H. Lee, R. Moriyama, R. Million, R. D. Palmiter, D. K. Clifton, R. A. Steine
  • Organizer: 2^<nd> World Conference of Kisspeptin signaling in the brain
  • Place of Presentation: University of Tokyo, Tokyo
  • Year and Date: 2012-11-07
• [Presentation] The requirement of Kiss1 for reproduction is sexually differentiated (2012)
  • Author(s): S. Popa, R. Moriyama, A. Oakley, C. Cho, M. Gottsch, T. Conception, D. Clifton, R. Steiner
  • Organizer: Northwest developmental biology meeting
  • Place of Presentation: Friday harbor laboratories, Washington
  • Year and Date: 2012-03-15
• [Presentation] Lysophosphatidic acid signaling is involved in neurite branch formation (2011)
  • Author(s): N. Fukushima, D. Furuta, M. Yamane, T. Tsujiuchi, R. Moriyama
  • Organizer: The 10th International conference on Alzheimer's and Parkinson's diseases (AD/PD 2011)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20110309-13
• [Presentation] Gonadal steroids down-regulate the long-chain fatty acid receptor GPR120 mRNA expression levels in gonadotrophs of the mouse anterior pituitary gland (2011)
  • Author(s): R. Moriyama, M. Toyonaga, T. Miyazato, Y. Sogo, N. Fukushima
  • Organizer: 44th Annual Meeting of the Society for the Study of Reproduction
  • Place of Presentation: Oregon Convention Center, Portland, Oregon, U.S.A.
  • Year and Date: 2011-08-02
• [Remarks]
  • URL: http://www.life.kindai.ac.jp/~mory/index.html