2012 Fiscal Year Final Research Report
Impact of endothelin-1 on bovine pregnancy: possible involvement of local regulation system of placental function
Project/Area Number |
23780284
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied animal science
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Research Institution | National Institute of Agrobiological Sciences |
Principal Investigator |
HAYASHI Kengo 独立行政法人農業生物資源研究所, 動物生産生理機能研究ユニット, 任期付研究員 (70563625)
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Project Period (FY) |
2011 – 2012
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Keywords | ウシ / 胎盤 / 妊娠 / エンドセリン |
Research Abstract |
Endothelin-1 (ET-1) is known as a most potent vasoconstrictor and participates in feto-placental growth and development during pregnancy. The aim of this study was to investigate physiological role of ET-1 in the regulation of placental function during pregnancy in cattle. The results of present study demonstrate that ET-1 is locally produced in bovine placenta and secreted into maternal circulation during pregnancy. In addition, ET-1 interacts with various vasoactive peptides, angiogenic factors and placental hormones within bovine placenta. These findings suggest a crucial role of ET-1 in the regulation of placental function and involvement of vasoactive substances including ET-1 on maintenance of bovine pregnancy.
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Research Products
(3 results)