2012 Fiscal Year Final Research Report
Discover ofnovel bioactive peptide and application-using model organism-
| Project/Area Number |
23780297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
IDA Takanori 宮崎大学, IR 推進機構, 助教 (00381088)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Noboru 宮崎大学, 農学部・獣医学科, 教授 (80150192)
SANO Hiroko お茶の水女子大学, お茶大アカデミック プロダクション, 特任助教 (90506908)
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| Research Collaborator |
TOMINAGA Hatsumi 宮崎大学, IR 推進機構, 技術職員
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| Project Period (FY) |
2011 – 2012
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| Keywords | 新規生理活性ペプチド / オーファンGPCR / ショウジョウバエ |
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| Research Abstract |
It is very important to discover a novel bioactive peptide to the orphan receptor. I have discovered 5 novel bioactive peptides in Drosophila, a useful model organism. I tried application to mammal, insect and crustacean. Therefore, I observed that dRYamide modulate feeding behavior and cardiovascular system in mouse and promote hiding sand behavior. CCHamide stimulate feeding behavior in insect.
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[Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-proteincoupled receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Kumiko Yoshizawa-Kumagaye, Hideki Nishio, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 414(1)
Pages: 44-48
DOI
Peer Reviewed
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[Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T,Kume K, Ozaki M, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 410(4)
Pages: 872-7
DOI
Peer Reviewed
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[Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophilaand their putative role in appetite regulation as ligands for G-protein-coupled receptors
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
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Journal Title
Frontiers in Eendocrinolin press
DOI
Peer Reviewed
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