2013 Fiscal Year Final Research Report
Involvement of MARCKS on methylmercury neurotoxicity and application as a marker for neurotoxicity
| Project/Area Number |
23780298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | メチル水銀 / MARCKS |
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| Research Abstract |
Because myristoylated alanine-rich C kinase substrate (MARCKS) plays an essential role in the differentiation and development of neuronal cells, we studied the alteration of MARCKS expression and phosphorylation in MeHg-induced neurotoxicity of neuroblastoma SH-SY5Y cells and in the rat brain. Exposure to MeHg induced a decrease in cell viability of SH-SY5Y cells, which was accompanied by an alteration of MARCKS phosphorylation and expression. In brain tissue from MeHg-treated rats, abnormal MARCKS phosphorylation was observed. The present study may indicate that alteration in MARCKS has consequences for MeHg-induced neurotoxicity.
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