2012 Fiscal Year Final Research Report
Analysis of interaction between novel prion protein (PrP) family Shadoo and PrP
| Project/Area Number |
23780299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 病原微生物 |
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| Research Abstract |
To investigate the influence of prion protein (PrP) expression on Shadoo (Sho) expression, the levels of Sho in PrP-deficient cell line (HpL) was analyzed before and after serum deprivation. In the presence of serum, the similar expression levels of Sho between HpL and HpL expressing PrP were observed, suggesting that the PrP expression did not affect the levels of Sho. In addition, serum deprivation did not change the expression levels of Sho in both HpL and HpL-PrP cells. These suggest anti-apoptotic function of PrP is independent of Sho expression.
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