2012 Fiscal Year Final Research Report
Breaking immunological tolerance to canine malignant melanoma using anti-Gpnmb antibody and various antigen peptides associated with tumor.
| Project/Area Number |
23780317
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 獣医学 / 臨床 / 癌 / 免疫学 / 生体分子 / 犬 |
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| Research Abstract |
We investigated new approachof immunological therapy for canine malignant melanoma, using anti-Gpnmb Ab and other various antigen peptides associated with tumor. The research showed that some peptides significantly activated T-lymphocytes compared to conventional method. However, the experiments with anti-Gpnmb Ab did not show notable results in T-cell activation. In the future research, we will thoroughly examine experimental conditions and intend to find more effective immunotherapy.
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