Development of novel molecular targeted therapy in canine malignant lymphoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 23780325
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical veterinary science
• Research Institution: Osaka Prefecture University
• Principal Investigator: AKIYOSHI Hideo 大阪府立大学, 生命環境科学研究科(系), 准教授 (50420740)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 犬 / リンパ腫 / 分子標的治療薬 / キメラ抗体

Outline of Final Research Achievements

Basic research was carried out in order to develop of novel molecular targeted therapies for canine malignant lymphoma as the final goal. The target molecule (CD20, CD25, and Syndecan 4) genes were cloned, and the gene expressions of these molecules in canine lymphoma tissues were evaluated. Moreover, In order to prepare the molecular targeted drugs (chimeric antibody) that bind to these molecules, canine IgG Fc genes were cloned, and recombinant proteins of the target molecules were prepared. Furthermore, the antibody display phage libraries against target molecules were prepared. Using these materials, the research is continuing for clinical applications.

Free Research Field

獣医外科学