2012 Fiscal Year Final Research Report
Basic research on establishing of novel diagnosis and therapy using ADAMTS13 in dog with thrombosis.
| Project/Area Number |
23780327
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical veterinary science
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ADAMTS13 / 犬 / 血栓症 |
|---|
| Research Abstract |
Human VWF73 is cleaved by canine ADAMTS13. And the decapeptide of the C-terminal edge of human VWF cleaved by canine ADAMTS13 is recognized by the anti-N10 antibody. Therefore the human ADAMTS13 activity ELISA kit, which consists of human VWF73 and anti-N10 antibody, could be applicable for measurement of plasma ADAMTS13 activity in dogs. Furthermore the ADAMTS13 activity in dogs with bacteremia was significantly lower than that in healthy dogs.
|
