2013 Fiscal Year Final Research Report
Analysis of ubiquitin modification regulating heterochromatin structure
| Project/Area Number |
23780351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIRAI Atsuko 独立行政法人理化学研究所, 眞貝細胞記憶研究室, 研究員 (60525575)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヘテロクロマチン / ユビキチン化修飾 / Cul4ユビキチンリガーゼ / ヒストンメチル化酵素 / RNA |
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| Research Abstract |
In eukaryotes, heterochromatin mediates diverse biological processes including gene silencing and regulation of long-range chromatin interaction. However, the mechanism underlying heterochromatin formation is poorly understood. Our study showed that non-cording RNA in mammals involved in heterochromatin formation and the subunit of highly conserved RNA polymerase II was ubiquitinated by Cul4 ubiquitin ligase.
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