2012 Fiscal Year Final Research Report
Catalytic Asymmetric Cyclopropenation using New Dirhodium(II) Complexes
| Project/Area Number |
23790001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
ANADA Masahiro 北海道大学, 大学院・薬学研究院, 准教授 (90344473)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 合成化学 / 不斉触媒反応 |
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| Research Abstract |
A new dirhodium(II) carboxylate complex [Rh_2(S-TBPTTL)_4] is an exceptionally effective catalyst for enantioselective cyclopropenation reactions of 1-alkynes with 2,4-dimethyl-3-pentyl α-alkyl-α-diazoacetates in preference to alkene formation via a 1,2-hydride shift, in which exceptionally high levels of asymmetric induction (up to 99% ee) as well as good to high chemoselectivities have been achieved.
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