2012 Fiscal Year Final Research Report
Development of Synthetic Methods for HeterocyclesUsing Palladium-Catalyzed C-H Functionalization
| Project/Area Number |
23790002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 触媒・化学プロセス / 有機化学 / パラジウム / C-H官能基化 / 複素環化合物 |
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| Research Abstract |
A novel catalytic method for synthesizing 4-aryl-2-quinolinones was developed that involves two mechanistically independent, sequential palladium-catalyzed reactions-the oxidative Heck reaction and the intramolecular C-H amidation-both of which smoothly proceeded in the presence of a single, palladium-based catalytic system. In addition, it was found that water can be successfully employed as a reaction medium in palladium-catalyzed C-H cyclization of thiobenzanilides. Reactions efficiently proceeded under considerably mild conditions in water, providing a more practical, greener method for the synthesis of 2-arylbenzothiazoles.
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