2012 Fiscal Year Final Research Report
Synthetic study of highly oxygenated diterpenes based on the bridgehead radical reaction
| Project/Area Number |
23790005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
URABE Daisuke 東京大学, 大学院・薬学系研究科, 助教 (80503515)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 全合成 / ラジカル反応 / 天然物 / 生理活性物質 / テルペン |
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| Research Abstract |
The C-C bond formation utilizing an alkoxy bridgehead carbon radical was developed. The high reactivity of the radical species realized the congested C-C bond formation to connect oxygenated carbocycles by two- and three-component reactions. Based on the strategy, the5/7/6-fused carbocycles of crotophorbolone, a tigliane diterpene, was successfully assembled in a stereoselective fashion.
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[Journal Article] Identification of and structure determination of a novel anti-inflammatory mediator resolvin E32012
Author(s)
Isobe, Y.; Arita, M.; Matsueda, S.; Iwamoto, R.; Fujiwara, T.; Nakanishi, H.; Taguchi, R.; Masuda, K.; Sasaki, K.; Urabe, D.; Inoue, M.; Arai, H
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Journal Title
The Journal of Biological Chemistry
Volume: 287
Pages: 10525-10534
DOI
Peer Reviewed
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