2014 Fiscal Year Final Research Report
Development of novel substrate-recognizable catalysts utilizing reversible formation of covalent bonds
| Project/Area Number |
23790016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MANABE Kei 静岡県立大学, 薬学部, 教授 (00251439)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 共有結合 / 基質認識 / ボロン酸 / ヒドロキシ基 / ヒドロエステル化 |
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| Outline of Final Research Achievements |
With expectation for a covalent bond to have strong interaction with substrates, novel catalysts that enabled formation and dissociation of covalent bonds were designed and synthesized. Application of these catalysts to catalytic organic reactions was also investigated. A ligand bearing boronic acid moiety was synthesized and could be, in principle, applicable to catalytic organic reactions by utilizing formation of boronic acid esters with alcohols. Furthermore, ester exchange strategy using an alcohol could work well in broadening of substrate generality to a great extent in Ru-catalyzed hydroesterification of alkenes using formates. Experimental mechanistic studies revealed for the first time the existence of multiple reaction pathways in the hydroesterification.
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| Free Research Field |
有機合成化学
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