2012 Fiscal Year Final Research Report
Syntheses of novel ligands regulating the interaction with VDR-LBD
| Project/Area Number |
23790021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ビタミン D / 合成化学 / 生理活性 / 有機化学 / 薬学 |
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| Research Abstract |
Convergent syntheses of several vitamin D analogs with a 15-substituent at CD-ring have been achieved. These syntheses are characterized as useful syntheses with the high efficiency and yield, so that other ligands would be synthesizedin these synthetic ways. Binding affinity for vitamin D receptor (VDR) of these ligands, transactivation activity of osteocalcin promoter in HOS cells, and X-ray crystallographic analysis of the complex with human VDR ligand binding domain have been also studied.
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