2013 Fiscal Year Final Research Report
Design of solid supported carbaborane catalyst with the aim of developing latent reactivity and reuse methods
| Project/Area Number |
23790034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | カルバボラン / 不均一系触媒 / 1,3-ジエン環化反応 / リサイクル / 再利用 / 水銀トリフラート |
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| Research Abstract |
We developed a novel heterogeneous catalyst, solid supported carbaboranylmercuric triflate, with the aim of reutilizing it. This solid supported catalyst showed the remarkable reactivities for aryl allyl alcohol cyclization, cyclization of N-tosylanilinoallylic alcohols, regioselective cycloisomerization of aryl- and hetero-substituted 1,3-dienes, tandem carbocyclization, and etc. The workup of these reactions was very simple, as the catalyst was recovered by filtration of the reaction mixture through ordinary filter paper. Moreover, the recovered catalyst was reused without significant loss of activity at least 20 times. In the case of decreasing the activity of the recovered catalyst through the process of reuse, it could be reactivated via the reaction with 2N hydrochloric acid and then silver triflate.
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Research Products
(13 results)
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[Journal Article] Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis2013
Author(s)
M. Oda, H. Imagawa, R. Kato, K. Yabiku, T. Yoshikawa, T. Takemoto, H. Takahashi, H. Yamamoto, M. Nishizawa, J. Sakurai, M. Nagahama. J. Enzym
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Journal Title
Inhib. Med. Chem
Volume: (Ahead of Print)
Pages: 1-8
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[Journal Article] Concise Synthesis of a Probe Molecule Enabling Analysis and Imaging of Vizantin2013
Author(s)
H. Yamamoto, M. Oda, M. Nakano, K. Yabiku, M. Shibutani, T. Nakanishi, M. Suenaga, M. Inoue, H. Imagawa, M. Nagahama, Y. Matsunaga, S. Himeno, K. Setsu, J. Sakurai, M. Nishizawa
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Journal Title
Chem. Pharm. Bull
Volume: 61
Pages: 452-459
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[Journal Article] Development of Vizantin, a Safe Immunostimulant, based on the Structure-Activity Relationship of Trehalose-6,6'-Dicorynomycolate2013
Author(s)
Yamamoto, H.; Oda, M.; Nakano, M.; Watanabe, N.; Yabiku, K.; Shibutani, M.; Inoue, M.; Imagawa, H.; Nagahama, M.; Himeno, S.; Setsu, K.; Sakurai, J.; Nishizawa, M
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Journal Title
J. Med. Chem
Volume: 56
Pages: 381-385
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[Journal Article] Syntheses of Stracturally-simplified and Fluore- scently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 cells2012
Author(s)
H. Imagawa, H. Saijo, H. Yamaguchi, K. Maekawa, T. Kurisaki, H. Yamamoto, M. Nishizawa, M. Oda, M. Kabura, M. Nagahama, J. Sakurai, M. Kubo, M. Nakai, K. Makino, M. Ogata, H. Takahashi, Y. Fukuyama
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 22
Pages: 2089-2093
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