2012 Fiscal Year Final Research Report
Development and medical applications of water-soluble supramolecular polymer utilizing molecular techniques of Spiroborates
| Project/Area Number |
23790035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 有機化学 |
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| Research Abstract |
As part of the new material development, including medical materials using supramolecular polymer, an alternative fat-soluble supramolecular polymer that already reported as "twinbowl", the research of preparation of water-soluble supramolecular polymer, crown ether-like spiroborate anions host, which is expected more robust than general crown ethers was perfomed. We prepared the precursor compound for the final cyclization step to give the crown ethers like spiroborate anion. Although the targeted cyclic spiroborate anion was not obtained, from many experimental trials, we found coexistence of suitable template molecule cations is very important in the cyclization reaction.
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