2013 Fiscal Year Final Research Report
Construction and elucidating of neural stem cell differentiation control substance library
| Project/Area Number |
23790036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KUBO Miwa 徳島文理大学, 薬学部, 講師 (00330754)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経栄養因子 / 神経幹細胞 / PC12細胞 |
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| Research Abstract |
As part of our continuing studies on neurotrophic-like active compounds in natural products, we investigated the chemical compounds with neurogenesis activities, resulting in the discovery of four compounds.Especially, jiadifenolide and honokiol significantly enhance neurite outgrowth in the primary cell cultures of fetal rat cortical neurons, respectively. These are worthy of note that both compounds have potential to significantly promote differentiation of multipotent neural stem cell line MEB5 cells into neurons. Furthermore, chronic treatment of phenylbutenoid dimer from Indonesian ginger enhanced hippocampal neurogenesis in dementia model OBX mice.
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[Journal Article] Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells2012
Author(s)
Imagawa, H., Saijo, H., Yamaguchi, H., Maekawa, K., Kurisaki, T., Yamamoto, H., Nishizawa, M., Oda, M., Kabura, M., Nagahama, M., Sakurai, J., Kubo, M., Nakai, M.; Makino, K.; Ogata, M.; Takahashi, H.; Fukuyama, Y
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 22(5)
Pages: 2089-2093
DOI
Peer Reviewed
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[Journal Article] Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis in olfactory bulbectomized mice2012
Author(s)
Matsui, N., Kido, Y., Okada, H., Kubo, M., Nakai, M., Fukuishi, N., Fukuyama, Y., Akagi, M
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Journal Title
Neuroscience Lett
Volume: 513(1)
Pages: 72-77
DOI
Peer Reviewed
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[Journal Article] Invasion inhibitors of human fibrosarcoma HT 1080 cells from the rhizomes of Zingiber cassumunar : structures of phenylbutanoids, cassumunols Chem2011
Author(s)
Matsuda, H., Nakamura, S., Iwami, J., Li, X., Pongpiriyadacha, Y., Nakai, M., Kubo, M., Fukuyama, Y., Yoshikawa, M
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Journal Title
Pharm. Bull
Volume: 59(3)
Pages: 365-370
DOI
Peer Reviewed
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[Journal Article] Asymmetric synthesis of (-)-chicanine using a highly regioselective intramolecular Mitsunobu reaction and revision of its absolute configuration2011
Author(s)
Harada, K., Hirouchi, H., Tanabe, K., Carter, R. G., Esumi, T., Kubo, M., Hioki, H., Fukuyama, Y
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Journal Title
Tetrahedron Lett
Volume: 52(23)
Pages: 3005-3008
DOI
Peer Reviewed
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[Journal Article] Asymmetric synthesis of (+)-machilin F by unusual stereoselective mitsunobu reaction2011
Author(s)
Harada, K., Kubo, N., Tanabe, K., Kubo, M., Esumi, T., Hioki, H., Fukuyama
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Journal Title
Heterocycles
Volume: 82(2)
Pages: 1127-1132
DOI
Peer Reviewed
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[Presentation] インドネシア産ショウガ科食用植物BANGLEの老化促進モデルマウスに対する空間学習記憶改善作用2014
Author(s)
仲井めぐみ,飯塚美知郎,平田歩,八木祐助,常風邪興平,横田淳子,吉岡三郎,原田研一,久保美和,福山愛保,宮村充彦
Organizer
日本薬学会第134年会
Place of Presentation
熊本
Year and Date
20140328-31
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