2012 Fiscal Year Final Research Report
Structural elucidation of the sequential signal transduction mechanism in two-component system
| Project/Area Number |
23790042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UEDA Takumi 東京大学, 大学院・薬学系研究科, 助教 (20451859)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 構造生物学 |
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| Research Abstract |
Our NMR study based on cross-saturation method revealed that the CheA-CheY complex, which regulates bacterial chemotaxis, exists in equilibrium between catalytic and non-catalytic states, in which their catalytic sites are close to and away from each other, respectively. This binding mode allows CheA to perform two signal transduction reactions with one catalytic site.
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