2012 Fiscal Year Final Research Report
Study on the mechanism of anti-angiogenesis and tumorigenesis through genomic function of nuclear receptor
| Project/Area Number |
23790075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAKAJIMA Yuka 筑波大学, 生命環境系, 助教 (40399499)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管新生 / 腫瘍形成 / エストロゲン受容体 |
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| Research Abstract |
I found that ER ligands suppress tumor angiogenesis of androgen independent prostate cancer through novel non-genomic pathway of ERβ, and thereby inhibit tumor growth. Moreover, I also found that NFκB is novel target gene of ERβ non-genomic pathway, and identified some inhibitory compounds of NFκB activity. These findings may provide a suitable target for androgen independent prostate cancer treatment.
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