2012 Fiscal Year Final Research Report
Analysis of a novel prepro-BDNF expression and function
| Project/Area Number |
23790080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
FUKUCHI Mamoru 富山大学, 大学院・医学薬学研究部(薬学), 助教 (40432108)
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| Project Period (FY) |
2011 – 2012
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| Keywords | BDNF / スプライシング |
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| Research Abstract |
In this study, I investigated the mechanism of mRNA expression of brain-derived neurotrophic factor （BDNF), which is involved in expressing a variety of neuronal functions. I found that RNA splicing of BDNF exon I-IX, which is one of alternative BDNF transcripts, was enhanced by Ca2+-CaMK signal evoked by neuronal activity. Moreover, a novel prepro-BDNF protein was generated from BDNF exon I-IX mRNA. These results provide a novel insight into BDNF expression in neurons
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