ROLE OF TRANSCRIPTION FACTOR NPAS4 IN DRUG DEPENDENCE

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790081
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Nagoya University
• Principal Investigator: NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
• Project Period (FY): 2011 – 2012
• Keywords: 薬物依存 / 転写因子 / メタンフェタミン

Research Abstract

It has been proposed that activity-dependent synaptic plasticity and remodeling of the mesolimbic dopaminergic system play a crucial role in the development of drug dependence. We previously reported that reduced Npas4 mRNA levels might contribute to impairments in memory and emotional behaviors induced by social isolation or restriction stress. In this study,we investigated pathophysiological role of NPAS4 in the drug dependence. Our results suggest that Npas4 plays an important role in the structural and functional plasticity of neurons. In addition, we assume that repeated administration of methamphetamine increases the expression levels of Npas4 in the hippocampus.

Research Products

• [Journal Article] Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I (2013)
  • Author(s): Yun, J., Nagai, T., Furukawa-Hibi, Y., Kuroda, K., Kaibuchi, K., Greenberg, M.E., Yamada, K
  • Journal Title: J. Biol. Chem Volume: 288 Pages: 2655-2664
  • Peer Reviewed
• [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice (2013)
  • Author(s): Ibi, D., Nagai, T., Nakajima, A., Mizoguchi, H., Kawase, T., Tsuboi, D., Kano, S.I., Sato, Y., Hayakawa, M., Lange, U.C., Adams, D.J., Surani, M.A., Satoh, T., Sawa, A., Kaibuchi, K., Nabeshima, T., Yamada, K
  • Journal Title: Glia Volume: 61 Pages: 679-693
  • Peer Reviewed
• [Journal Article] Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex (2012)
  • Author(s): Toriumi, K., Mouri, A., Narusawa, S., Aoyama, Y., Ikawa, N., Lu, L., Nagai, T., Mamiya, T., Kim, H.C., Nabeshima, T
  • Journal Title: Neuropsychopharmacology Volume: 37 Pages: 1387-1396
  • Peer Reviewed
• [Journal Article] Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice (2012)
  • Author(s): Takuma, K., Mizoguchi, H., Funatsu, Y., Hoshina, Y., Himeno, Y., Fukuzaki, E., Kitahara, Y., Arai, S., Ibi, D., Kamei, H., Matsuda, T., Koike, K., Inoue, M., Nagai, T., Yamada, K
  • Journal Title: Neuroscience Volume: 207 Pages: 261-273
  • Peer Reviewed
• [Journal Article] Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice (2012)
  • Author(s): Takuma, K., Mizoguchi, H., Funatsu, Y., Kitahara, Y., Ibi, D., Kamei, H., Matsuda, T., Koike, K., Inoue, M., Nagai, T., Yamada, K
  • Journal Title: J. Pharmacol. Sci Volume: 120 Pages: 89-97
  • Peer Reviewed
• [Journal Article] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter (2012)
  • Author(s): Furukawa-Hibi, Y., Yun, J., Nagai, T., Yamada, K
  • Journal Title: J. Neurochem Volume: 123 Pages: 866-875
  • Peer Reviewed
• [Journal Article] D-serine ameliorates neonatal polyI:C treatment-induced emotional and cognitive impairments in adult mice (2012)
  • Author(s): Nagai, T., Yu, J., Kitahara, Y., Nabeshima T., Yamada, K
  • Journal Title: J. Pharmacol. Sci Volume: 120 Pages: 213-227
  • Peer Reviewed
• [Journal Article] Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats (2012)
  • Author(s): Zhang, L., Nagai, T., Yamada, K., Ibi, D., Ichihara, S., Subramanian, K., Huang, Z., Mohideen, S.S., Naito, H., Ichihara G
  • Journal Title: Toxicology Volume: 304C Pages: 76-82
  • Peer Reviewed
• [Journal Article] Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment (2011)
  • Author(s): Nagai, T., Kitahara, Y., Ibi, D., Nabeshima, T., Sawa, A., Yamada, K
  • Journal Title: Behav. Brain Res Volume: 225 Pages: 305-310
  • Peer Reviewed
• [Journal Article] Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse (2011)
  • Author(s): Kuroda, K., Yamada, S., Tanaka, M., Iizuka, M., Yano, H., Mori, D., Tsuboi, D., Nishioka, T., Namba, T., Iizuka, Y., Kubota, S., Nagai, T., Ibi, D., Wang, R., Enomoto, A., Isotani-Sakakibara,M., Asai, N., Kimura, K., Kiyonari, H., Abe, T., Mizoguchi, A., Sokabe, M., Takahashi, M., Yamada, K., Kaibuchi, K
  • Journal Title: Hum. Mol. Genet Volume: 20 Pages: 4666-4683
  • Peer Reviewed
• [Journal Article] Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice (2011)
  • Author(s): Koseki, T., Mouri, A., Mamiya, T., Aoyama, Y., Toriumi, K., Suzuki, S., Nakajima, A., Yamada, T., Nagai, T., Nabeshima, T
  • Journal Title: Int. J. Neuropsychopharmacol Volume: 18 Pages: 1-13
  • Peer Reviewed
• [Presentation] ドパミン作動性およびグルタミン酸作動性神経伝達の変調と障害に関する神経精神薬理学的研究 (日本神経精神薬理学会 2012 年 第1回学術奨励賞受賞講演) (2012)
  • Author(s): 永井拓
  • Organizer: 第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 宇都宮,栃木県総合文化センター/宇都宮東武ホテルグランデ
  • Year and Date: 20121018-20
• [Presentation] 精神疾患モデル動物を用いた神経精神薬理学的研究 (特別講演) (2012)
  • Author(s): 永井拓
  • Organizer: 第16回日本神経麻酔・集中治療研究会
  • Place of Presentation: 岡山,岡山コンベンションセンター/岡山大学
  • Year and Date: 20120413-14
• [Presentation] プロテアーゼを介した薬物依存形成の神経化学的機序 (2011)
  • Author(s): 永井拓
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京,京王プラザホテル
  • Year and Date: 20111027-29
• [Presentation] 周産期における異常免疫応答と神経発達障害 (2011)
  • Author(s): 永井拓
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京,京王プラザホテル
  • Year and Date: 20111027-29
• [Presentation] Npas4 regulates neurite outgrowth and phosphorylation of synapsinI (2011)
  • Author(s): 尹錫在, 永井拓, 日比陽子, 黒田啓介, 貝淵弘三, 山田清文
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京,京王プラザホテル
  • Year and Date: 20111027-29
• [Presentation] 神経精神発達に対する幼若期ストレスの影響 (2011)
  • Author(s): 永井拓, 尹錫在, 日比陽子, 山田清文
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 加賀, 瑠璃光
  • Year and Date: 20110926-28
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/pharmacy/02/index.html