2012 Fiscal Year Final Research Report
Research for reward-basis decision making in drug abuse-dependent rat
| Project/Area Number |
23790082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 意思決定 / 薬物依存症 / 覚せい剤 / ギャンブル試験 / 島皮質 / 線条体 |
|---|
| Research Abstract |
In the present study, we developed a gambling test for rodents using a radial-arm maze to address the issue of decision-making in patients with drug dependence. Our findings suggest that chronic methamphetamine treatment may lead to alternations of reward-based decision-making. Aberrant activation of the cortico-striatal pathway from insular cortex to striatum may be associated with the impairment of reward-based decision-making in methamphetamine-dependent rats.
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Research Products
(10 results)
