2012 Fiscal Year Final Research Report
The exploration of antidepressant effects in the hypothalamic nuclei
| Project/Area Number |
23790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
SEGI Eri 京都大学, 大学院・薬学研究科, 特定准教授 (70378628)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経生物学 / 抗うつ治療 / 遺伝子発現 / 視床下部 / 摂食 |
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| Research Abstract |
The purpose of the study is to explore antidepressant effects of electroconvulsive seizures (ECS) in the hypothalamic nuclei.
(1) ECS down-regulates gene expression of cholecystokinin, which is suggested as a modulator of the stress responses, in the paraventricular hypothalamus.
(2) ECS up-regulates gene expression of anorexigenic factors in the ventromedial hypothalamus, and decreases food intake via ventromedial hypothalamus function. This study suggests a role in the regulation energy homeostasis by ECS.
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