2013 Fiscal Year Final Research Report
Molecular pharmacological analyses of CRTH2, the type II PGD2 receptor, as a molecule regulating emotional function
| Project/Area Number |
23790086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | PGD2 / 情動機能 / 認知機能 / sickness behavior / 統合失調症 / うつ病 / ノルアドレナリン / ノックダウン |
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| Research Abstract |
Although accumulating evidences established stimulatory roles of prostanoid receptor CRTH2 in peripheral inflammation, its brain function is poorly understood. This study has revealed the specific involvement of brain CRTH2 in the emotional impairment in mice sickness behavior models, and its possible roles in the regulation of cognition both in experimental animals and human subjects. This study has also developed a knockdown system of CRTH2 etc., which will contribute to further molecular analysis of CRTH2 in the central nervous system.
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[Journal Article] Central CRTH2, a Second Prostaglandin D2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model2014
Author(s)
Ryota Haba, Norihito Shintani,Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba.
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Journal Title
Journal of Neuroscience
Volume: 34(7)
Pages: 2514-2523
Peer Reviewed
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[Presentation] Altered cognitive function in mice lacking prostanoid receptor DP22013
Author(s)
Yusuke Onaka, Takuya Kanoh, Norihito Shintani, Risa Takenaga, Ryota Haba, Atsuko Hayata, Atsushi Kasai, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Akemichi Baba, Hitoshi Hashimoto
Organizer
Neuro2013
Place of Presentation
京都国際会議場(京都府)
Year and Date
2013-06-22
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[Presentation] Selective involvement of prostanoid receptor CRTH2 in depression-like behaviors2012
Author(s)
Norihito Shintani, Yusuke Onaka, Risa Takenaga, Takuya Kanoh, Ryota Haba, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Akemichi Baba, Hitoshi Hashimoto
Organizer
The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry, The 55th Annual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
2012-10-01
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