2013 Fiscal Year Final Research Report
The role of basic fibroblast growth factor in regulation of metabolism of adipocyte
| Project/Area Number |
23790089
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
KIHIRA Yoshitaka 徳島大学, ヘルスバイオサイエンス研究部, 助教 (90377276)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 塩基性繊維芽細胞増殖因子 / 低酸素誘導因子 / 肥満 / 糖尿病 |
|---|
| Research Abstract |
We observed that basic fibroblast growth factor dysregulates glucose metabolism of adipocyte via expression of hypoxia-inducible factor-1alpha, indicating that expression of hypoxia-inducible factor-1alpha involves in development of diabetes mellitus. Therefore, we prepared an adipocyte-specific hypoxia inducible factor-1alpha knockout mice and observed the phenotype. The mice exhibited improved insulin sensitivity and glucose tolerance under obese conditions compared with wild type mice. These results suggested that hypoxia-inducible factor-1alpha plays an important role in development of obesity-induced diabetes.
|
Research Products
(13 results)
-
[Journal Article] Deletion of hypoxia-inducible factor-1αin adipocytes enhances glucagon-like Peptide-1 secretion and reduces adipose tissue inflammation2014
Author(s)
Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, Sakaue H, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S
-
Journal Title
PLoS One
Volume: 9(4)
Pages: 93856
Peer Reviewed
-
-
[Presentation] 腸管L細胞のグルカゴン様ペプチド-1分泌に対する低酸素の影響2014
Author(s)
木平孝高, BURENTOGTOKH Ariunzaya,伊藤麻里,山野範子,石澤有紀,石澤啓介,池田康将,土屋浩一郎,玉置俊晃
Organizer
日本薬学会第134年会
Place of Presentation
熊本県,ホテル日航熊本,熊本大学黒髪キャンパス,熊本市総合体育館
Year and Date
20140327-30
-
-
[Presentation] Adipocyte-specific hypoxia-inducible factor-1alpha knockout stimulated GLP-1 and insulin secretions in mice2013
Author(s)
保科耀司,木平孝高,冨田修平,三宅真理子,山野範子,石澤有紀,石澤啓介,池田康将,土屋浩一郎,玉置俊晃
Organizer
第86回日本薬理学会年会
Place of Presentation
福岡県,福岡国際会議場
Year and Date
20130321-23
-
-
[Presentation] 脂肪細胞特異的低酸素誘導因子欠損マウスに観察される耐糖能の改善にはglucagon-like peptide-1が関与する2013
Author(s)
木平孝高,冨田修平,三宅真理子,保科耀司,山野範子,石澤有紀,石澤啓介,池田康将,土屋浩一郎,玉置俊晃
Organizer
第42回日本心脈管作動物質学会
Place of Presentation
奈良県,奈良県立新公会堂
Year and Date
20130208-09
-
-
-
-
-
[Presentation] Glucose Metabolism of Adipocytes is Regulated by Basic Fibroblast Growth Factor via Hypoxia-inducible Factor-1a2011
Author(s)
Yamaguchi K, Kihira Y, Yamano N, Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tomita S, Tamaki T
Organizer
High Blood Pressure Research Scientific Sessions 2011 Scientific Sessions
Place of Presentation
USA, Orlando, Fla. Walt Disney World Dolphin Resort
Year and Date
20110920-24
-
