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2013 Fiscal Year Final Research Report

Novel roles of chronic inflammatory factor CYLD in lung fibrosis

Research Project

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Project/Area Number 23790091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionKumamoto University

Principal Investigator

JONO Hirofumi  熊本大学, 医学部附属病院, 准教授 (40515483)

Project Period (FY) 2011 – 2013
Keywords肺線維症 / CYLD / 慢性炎症 / TGF / 腫瘍抑制遺伝子 / 脱ユビキチン化酵素
Research Abstract

Lung Fibrosis, a fatal progressive pathological condition caused by chronic inflammation, is deeply-involved in the pathogenesis of various kinds of pulmonary diseases. In this study, we focused on CYLD, a novel chronic inflammatory factor, and elucidated the molecular pathogenesis of lung fibrosis. We revealed that, 1. Loss of CYLD promoted lung fibrosis via overproduction of fibrotic response gene, 2. Loss of CYLD caused overproduction of fibrotic response gene via increasing Smad3 protein expression by suppressing Smad3 degradation. Those results suggest that CYLD regulates the fibrotic response gene expressopn and plays important roles in the molecular pathogenesis of lung fibrosis.

  • Research Products

    (23 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Clinical Significance of CYLD Downregulation in Breast Cancer2014

    • Author(s)
      Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li J-D, Iwase H, Ando Y.
    • Journal Title

      Breast Cancer Res. Treat

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Stromal Expression of Neutrophil Gelatinase-Associated Lipocalin Correlates with Poor Differentiation and Adverse Prognosis in Oral Squamous Cell Carcinoma2014

    • Author(s)
      Shinriki S, Jono H , Ueda M, Obayashi K, Nakamura T, Ota K, Ota T, Sueyoshi T, Guo J, Hayashi M, Hiraki A, Nakayama H, Yamashita S, Shinohara M, Ando Y
    • Journal Title

      Histopathology

      Volume: 64 Pages: 356-64

    • Peer Reviewed
  • [Journal Article] CYLD down-regulation is correlated with tumor development in patients with hepatocellular carcinoma2013

    • Author(s)
      Kinoshita H, Okabe H, Beppu T, Chikamoto A, Hayashi H, Imai K, Mima K, Nakagawa S, Yokoyama N, Ishiko T, Shinriki S, Jono H, Ando Y, Baba H
    • Journal Title

      Molecular and Clinical Oncology

      Pages: 309-314

    • Peer Reviewed
  • [Journal Article] Suppression of inflammation via PDE4B-JNK2-dependent upregulation of deubiquitinase CYLD2013

    • Author(s)
      Komatsu K, Lee J, Miyata M, Lim JH, Jono H, Koga T, Xu H, Yan C, Kai H, Li JD
    • Journal Title

      Nature Commun

      Volume: 4 Pages: 1684

    • Peer Reviewed
  • [Journal Article] PDE4B mediates ERK dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA dependent MKP-1 pathway2012

    • Author(s)
      Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 22799-811

    • Peer Reviewed
  • [Journal Article] CYLD Negatively Regulates Transforming Growth Factor-B Signaling via Deubiquitinating Akt2012

    • Author(s)
      Lim JH, Jono H, Komatsu K, Dr. Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD
    • Journal Title

      Nature Commun

      Volume: 3 Pages: 771

    • Peer Reviewed
  • [Journal Article] Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts2012

    • Author(s)
      Okabe H, Beppu T, Ueda M, Hayashi H, Ishiko T, Masuda T, Otao R, Horlad H, Mima K, Miyake K, Iwatsuki M, Baba Y, Takamori H, Jono H, Shinriki S, Ando Y, Baba H
    • Journal Title

      Int J Cancer

      Volume: 131 Pages: 2234-41

    • Peer Reviewed
  • [Journal Article] Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma2012

    • Author(s)
      Ota T, Jono H, Ota K, Shinriki S, Ueda M, Sueyoshi T, Nakatani K, Fujita S, Obayashi K, Shinohara M, Ando Y
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 1674-80

    • Peer Reviewed
  • [Journal Article] PKCθsynergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA12012

    • Author(s)
      Jono H, Lim JH, Xu H, Li JD
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: 31049

    • Peer Reviewed
  • [Journal Article] Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma2012

    • Author(s)
      Sueyoshi T, Jono H, Shinriki S, Ota K, Ota T, Tasaki M, Atsuyama E, Yakushiji T, Ueda M, Obayashi K, Mizuta H, Ando Y
    • Journal Title

      Cancer Lett

      Volume: 316 Pages: 23-30

    • Peer Reviewed
  • [Journal Article] Effects of a Novel Nonantibiotic Macrolide,EM900, on Cytokine and Mucin Gene Expression in a Human Airway Epithelial Cell Line2011

    • Author(s)
      Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K
    • Journal Title

      Pharmacology

      Volume: 88 Pages: 327-332

    • Peer Reviewed
  • [Journal Article] Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells2011

    • Author(s)
      Okabe H, Beppu T, Hayashi H, Ishiko T, Masuda T, Otao R, Horlad H, Jono H, Ueda M, Phd SS, Ando Y, Baba H
    • Journal Title

      Ann Surg Oncol

      Volume: 18 Pages: 1175-1184

    • Peer Reviewed
  • [Presentation] Signal transduction mechanisms and their tight regulation in nontypeable Haemophilus influenzae2013

    • Author(s)
      Jono H
    • Organizer
      infection 2013 International Meeting of the Microbiological Society of Korea
    • Place of Presentation
      Jeonju city, Korea
    • Year and Date
      2013-05-01
  • [Presentation] Uncovering host epithelial signaling networks by respiratory bacterial pathogens2013

    • Author(s)
      Jono H
    • Organizer
      World-Class University & 5th microbial pathogenesis & immunity symposium
    • Place of Presentation
      Su-Won, Korea
    • Year and Date
      2013-04-30
  • [Presentation] Loss of CYLD promotes cell migration through stabilized ALK5 in human oral squamous cell2013

    • Author(s)
      Shinriki S, Jono H, Li J-D, Nakamura T, Hayashi M, Guo J, Shinohara M, Ando Y
    • Organizer
      carcinoma AACR Annual meeting
    • Place of Presentation
      Washington, USA
    • Year and Date
      2013-04-06
  • [Presentation] 骨肉腫におけるがん抑制遺伝子CYLDの生物学的活性の解明2013

    • Author(s)
      城野博史、末吉貴直、神力悟、厚山恵里、柳澤哲大、薬師寺俊剛、田崎雅義、大林光念、水田博志、安東由喜雄
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2013-03-27
  • [Presentation] Loss of tumor suppressor CYLD triggers cell invasion of human oral squamous cell carcinoma cells2013

    • Author(s)
      城野博史、神力悟、大林光念、安東由喜雄
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2013-03-21
  • [Presentation] 頭頸部扁平上皮癌におけるがん抑制遺伝子CYLD発現低下の臨床的意義の解2012

    • Author(s)
      城野博史、神力悟、大林光念、田崎雅義、安東由喜雄
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本,熊本大学薬学部
    • Year and Date
      2012-11-23
  • [Presentation] 骨肉腫進展におけるCYLDの関与と生物学的意義の解明2012

    • Author(s)
      城野博史、末吉貴直、神力悟、厚山恵里、柳澤哲大、薬師寺俊剛、田崎雅義、大林光念、水田博志、安東由喜雄
    • Organizer
      第52回臨床化学会年会
    • Place of Presentation
      いわて県民情報交流センターアイーナ、盛岡
    • Year and Date
      2012-09-06
  • [Presentation] 低酸素環境における腫瘍抑制遺伝子cylincromatosis (CYLD)の発現異常2011

    • Author(s)
      郭建エイ,神力悟,城野博史,厚山恵理,太田和俊,太田智子,中村拓哉,大林光念,安東由喜雄
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場、愛知
    • Year and Date
      2011-10-03
  • [Presentation] 低酸素環境における腫瘍抑制遺伝子cylincromatosis (CYLD)の発現異常2011

    • Author(s)
      津田幸元,神力悟,村上慶高,城野博史,安東由喜雄
    • Organizer
      第51回臨床化学会年会
    • Place of Presentation
      札幌医科大学、札幌
    • Year and Date
      2011-08-28
  • [Presentation] Cylincromatosis(CYLD)発現低下は口腔扁上皮癌の血管新生を誘導する2011

    • Author(s)
      村上慶高,神力悟,津田幸元,城野博史,安東由喜雄
    • Organizer
      第51回臨床化学会年会
    • Place of Presentation
      札幌医科大学、札幌
    • Year and Date
      2011-08-28
  • [Remarks]

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/pharmacy/default.html

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Published: 2015-06-25  

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