2013 Fiscal Year Final Research Report
Photoaffinity labeling of sphingosine 1-phosphate transporters
| Project/Area Number |
23790093
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Teikyo Heisei University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | スフィンゴシン１リン酸 / 輸送体 / トランスポーター |
|---|
| Research Abstract |
Sphingosine 1-phosphate (S1P) is a bioactive signal transmitter present in blood. Blood plasma S1P plays important roles in immune system and angiogenesis. Erythrocytes and platelets synthesize and secrete S1P. However, the S1P transporters of erythrocytes and platelets have not been identified. The S1P transporters are attractive candidates for drug target. In this study, we performed photoaffinity labeling of erythrocyte and platelet proteins with photoreactive S1P analogs. We showed that the S1P transporter, SPNS2 is selectively labeled by the photoreactive S1P analog.
|
