2012 Fiscal Year Final Research Report
Evaluation of a novel anti-histone H1 monoclonal antibody generated from a peptide mimotope as an immunosuppressant for organ transplantation.
| Project/Area Number |
23790094
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Josai International University |
|---|
Principal Investigator |
SHIMADA Yayoi 城西国際大学, かずさ創薬研究センター, 研究員 (70439024)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 免疫抑制剤 / 抗体医薬 |
|---|
| Research Abstract |
The purposes of this study were to evaluate a novel anti-histone H1 monoclonal antibody (SSV mAb) generated from a peptide mimotope as an immunosuppressant for organ transplantation using experimental animals and to elucidate the mechanism of immunosuppression by SSV mAb. SSV mAb suppressed mixed lymphocyte reaction using rat splenocytes in a way that is independent of IL-2. SSV mAb recognized three Cell surface antigens on rat splenocytes. Treatment with SSV mAb did not prevent acute rejection in heterotopic heart transplanted rats. From this result, I conclude that SSV mAb does not work as an immunosuppressant in vivo.
|
Research Products
(9 results)
-
[Journal Article] Unexpected T cell regulatory activity of anti-histone H1 autoantibody: its mode of action in regulatory T cell-dependent and -independent manners2013
Author(s)
Takaoka Y., Kawamoto S., Katayama A., Nakano T., Yamanaka Y., Takahashi M., Shimada Y., Chiang K. C., Ohmori N., Aki T., Goto T., Sato S., Goto S., Chen C. L., Ono K.
-
Journal Title
Biochemical and Biophysical Research Communications
Volume: 432(2)
Pages: 246-252
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
