Functional analysis of GPR55 and GPR35, novel lysophospholipid receptors

2015 Fiscal Year Final Research Report

• Project/Area Number: 23790101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Teikyo University
• Principal Investigator: Oka Saori 帝京大学, 薬学部, 講師 (80439562)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: リゾリン脂質 / GPR55 / アラキドン酸 / カンナビノイド / リゾホスファチジルイノシトール

Outline of Final Research Achievements

GPR55 is a putative novel cannabinoid receptor and its endogenous ligand is lysophosphatidylinositol (LPI). This study demonstrated that the level of 2-arachidonlyl LPI was predominantly eleveted in mouse splenocytes stimulated with mitogen, mouse plasma, and the site of allergic inflammation using LC-MS/MS analysis. Because GPR55 is expressed mainly in the immune system and the biological activity of 2-arachidonoyl LPI is higher than those of other molecular species, 2-arachidonoyl LPI may play important roles in inflammation and immunity.

Free Research Field

脂質生化学