2012 Fiscal Year Final Research Report
Activation mechanism of nuclear receptor CAR by xenobiotics and CAR-mediated disruption of energy metabolism
| Project/Area Number |
23790104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写因子 / 分子生物学 / 代謝調節 / 核内受容体 / 環境衛生系薬学 / 環境毒性学 |
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| Research Abstract |
The constitutive androstane receptor (CAR) plays an important role of a defence mechanism against the toxicity of xenobiotics. In this study, we identified novel CAR binding proteins, which were AMPKβ, DP97, PRMT5 and Hsp60. We showed DP97 and PRMT5 act as a gene (or promoter)-selective co-activators for CAR. Furthermore, we showed the basal transcriptional activity of unliganded CAR was shown to be repressed by the potent liver X receptor (LXR) agonist, T0901317
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