2012 Fiscal Year Final Research Report
The role of uPAR in the inflammation-induced bone resorption
| Project/Area Number |
23790107
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KANNO Yosuke 同志社女子大学, 薬学部, 助教 (40416178)
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| Project Period (FY) |
2011 – 2012
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| Keywords | LPS / uPAR / 炎症性骨破壊 |
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| Research Abstract |
The aim of this study was to clarify the role of uPAR on the LPS-indeuced bone resorption. We found that LPS induced the expression of uPAR in osteoclasts, but LPS did not inducethe expression of uPAR in osteoblasts. We also found that the reduction of uPAR attenuated the LPS-induced NF-kB activation, and uPAR overexpression promoted the LPS- induced NF-kB activity. In addition, we demonstrated that the binding of uPA/uPAR regulates the LPS-induced NF-kB activation and osteoclast differentiation. Moreover, we found that uPAR is associated with LPS-induced RANKL expression in osteoblasts.
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