2012 Fiscal Year Final Research Report
The vitamin K biosynthetic mechanism in brain and its relevance to neurodegenerative disease
| Project/Area Number |
23790110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子栄養学 |
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| Research Abstract |
Vitamin K is a cofactor for γ-glutamyl carboxylase (GGCX), which catalyses the post-translational modifications of several vitamin K-dependent proteins, such as coagulation factors, osteocalcin and matrix Gla protein. We recently confirmed that the PK to MK-4 conversion took place in slice culture of mouse cerebra and primary culture of mouse cerebral hemispheres. Moreover, we identified MK-4 biosynthetic enzyme [UbiA prenyltransferase domain containing 1 (UBIAD1)]. In this study, we analyzed the function of MK-4 biosynthetic enzyme in brain and the relationship of vitamin K and neurodegenerative disease. As a result, we indicated that MK-4 and MK-4 biosynthetic enzyme may have a important rule in brain.
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