2012 Fiscal Year Final Research Report
The role and mechanisms of Fgf21 as the metabolic regulator in white adipose tissue
| Project/Area Number |
23790111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | Fgf / 白色脂肪組織 / ケトン食 / 糖代謝 / インスリン抵抗性 / Fgf21 |
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| Research Abstract |
A low-carbohydrate, high-fat ketogenic diet (KD) induces hepatic ketogenesis and is believed to affect energy metabolism in mice. As hepatic Fgf21 expression was markedly induced in mice fed KD, we examined the effects of KD feeding on metabolism and the roles of Fgf21 in metabolism in mice fed KD using Fgf21 knockout mice. The present findings indicate that KD feeding impairs insulin sensitivity in mice due to insulin resistance in white adipose tissue. In addition, our findings indicate that Fgf21 induced to express by KD is a negative regulator of adipocyte insulin sensitivity in adaptation to a low-carbohydrate malnutritional state.
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[Journal Article] Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as amitokine.2013
Author(s)
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM,Kim YN, Kim SS, Kim do H, Hur KY, Kim HK,Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS.
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Journal Title
Nature Medicine
Volume: 19
Pages: 83-92
DOI
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